Maximum Likelihood Estimationwith a Parametric Noise Covariance Model for Instantaneous and Spatio-temporal Electromagnetic Source Analysis

In instantaneous encephalogram or magnetoencephalogram (EEG/MEG) source analysis, ordinary least squares estimation (OLS) requires that the spatial noise is homoscedastic and uncorrelated over sensors. In spatio-temporal analysis OLS also requires that the noise is homoscedastic and uncorrelated in time (over samples). Generally, these assumptions are violated and, as a consequence, OLS can give rise to inaccuracies in the estimates of location and moment paramaters of sources underlying the EEG/MEG. To improve these estimates of the sources, generalized least squares (GLS) was developed, which uses the spatial or spatio-temporal noise covariances. In GLS these noise covariances are estimated from trial variation around the mean. Therefore, GLS requires many trials to accurately estimate the spatial noise covariances and thus the source parameters. Alternatively, with Maximum Likelihood (ML) the spatial or spatio-temporal noise covariances can be modeled parametrically. Here, only the modelparameters describing the noise covariances need to be estimated. Consequently, fewer trials are required to obtain accurate noise covariances and consequently accurate source parameters. In this paper ML estimation for spatio-temporal analysis is derived, and it is shown that the noise and source parameters can be estimated separately. Furthermore, the likelihood ratio function is proposed to estimate the spatial or spatio-temporal noise covariance model parameters, which can also be used to test whether the model is adequate. The Netherlands Organization for Scienti c Research (NWO) is gratefully acknowledged for funding this project. This research was conducted while Lourens Waldorp was supported by a grant of the NWO foundation for Behavioral and Educational Sciences of this organization (527-25-013) awarded to Hilde Huizenga. The research has been made possible by fellowships of the Royal Netherlands Acadamy of Arts and Sciences to Hilde Huizenga and Conor Dolan.